The problem of diagnosing mental disorders is reduced to subjective factors, despite the high degree of prevalence of such diseases. Thus, the idea of creating a multi-marker diagnostic device for such diseases is in great demand. In this study, the optical sensor on the glutamic acid for schizophrenia detection was developed considered. Two different glutamate oxidase (GOD) and glutamate dehydrogenase (GDH) enzymes were tested. In the first case, the optical response was related to the formation of peroxocomplexes of H2O2 with TiO2, in the second case, it is due to a color change in the complexation reaction of metal cations with ammonium. Various paper options as a substrate were considered, and a matrix was selected. Obtaining the optimal parameters for the optical biosensor.
Гончаренко А.О., Скворцова Н.Н., Морозова С.М. (науч. рук. Виноградов А.В.) Inkjet printing of optical biosensors for mental disorders detecting // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2020]. URL: https://kmu.itmo.ru/digests/article/4010