This paper presents the concept of combined DNA technology and RNA interference (RNAi) for developing a DNA nanomachine based on shRNA capable of regulating the expression of a target gene only in the presence of a marker sequence. This system can become the foundation for the development of new RNAi agents with high efficiency and selectivity towards suppression of cancer cells.
Смирнов В., Эльдиб А.А., Дрозд В.С., Патра Х.К. (науч. рук. Колпащиков Д.М.) DESIGN OF A DNA MACHINE BASED ON SHRNA FOR MARKER-DEPENDENT RNA INTERFERENCE // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2022]. URL: https://kmu.itmo.ru/digests/article/9154