A big branch of therapeutic nucleic acid (TNA) research is correlated to developing stable and effective delivery systems for these gene therapy drug products to the targeted cells. While currently used delivery systems may exert significant toxicity for the surrounding tissues and face the significant obstacle of endosomal escape, bioconjugates are emerging as non-toxic alternatives with great potential in this field. We aim to investigate cholesterol integrated into DNA nanostructures as a delivery system for TNAs.
Патра Х.К., Недорезова Д.Д., Эльдиб А.А. (науч. рук. Колпащиков Д.М.) INVESTIGATION OF INTRACELLULAR DELIVERY OF THERAPEUTIC NUCLEIC ACIDS WITH THE HELP OF LIPID CONJUGATES AND DNA NANOSTRUCTURES // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2022]. URL: https://kmu.itmo.ru/digests/article/8701