High-gravity fermentation enhances ethanol productivity but imposes intense osmotic and metabolic stress on Saccharomyces cerevisiae, leading to reduced viability and premature cellular senescence. This study proposes application of pulsed ultrasonic treatment (PUT) during early fermentation to bolster yeast longevity and process performance. Based on emerging evidence that low-intensity ultrasound can modulate membrane permeability, enhance stress tolerance, and improve metabolic activity in yeast systems, we hypothesize that pulsed exposure will (i) mitigate osmotic and ethanol-induced stress, (ii) reduce rates of viability loss, and (iii) maintain fermentative performance under high sugar concentrations.

Аббар А. (науч. рук. Ишевский А.Л.) Enhancing yeast viability and fermentation performance in high-gravity brewing via pulsed ultrasonic treatment: mechanisms of stress protection and longevity extension // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2026]. URL: https://kmu.itmo.ru/digests/article/17900