Cisplatin is an effective anticancer drug; however, its major drawback is kidney damage, known as nephrotoxicity. This condition primarily results from oxidative stress, inflammation, and apoptosis. The present study investigates the nephroprotective effects of Cucumeropsis mannii seed oil. The study involved physicochemical characterization, including spectroscopy confirming triacylglyceride structure and phenolic contents. The oil demonstrated rapidly scavenging kinetics. It markedly attenuated renal inflammation, reducing IL-1β, IL-6, TNF-α, and NF-κB levels near to control values. Apoptosis was concurrently suppressed, with decreased caspase-3 and caspase-9 activity, lowered Bax expression, and preserved Bcl-2 levels. These findings support CMSO's potential as complementary therapy.

Але Б. (науч. рук. Смирнов Е.А.) Nephroprotective effects of cucumeropsis mannii seed oil: physicochemical characterization and mechanistic insights // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2026]. URL: https://kmu.itmo.ru/digests/article/16585