This study focuses on developing a 7-input DNA nanomachine designed for cancer diagnosis and treatment. By using DNAzyme-based constructions, the project introduces a threshold activation mechanism that only triggers when the input molecule concentration reaches a specific level. The nanomachine, designed to cleave synthetic RNA, relies on thermodynamic principles to ensure accurate activation. The results demonstrate the potential of these 7-input DNA nanomachines as a promising tool for gene therapy in cancer treatment.

Валеева Ю.Р., Мустафа А. (науч. рук. Эльдиб А.А.) Developing thresholding dna nanomachine for cancer diagnosis and treatment // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2025]. URL: https://kmu.itmo.ru/digests/article/15653