This work explores the innovative use of DNA origami in creating marker-activated nanomachines for targeted cancer therapy. By folding DNA into precise structures, the research introduces a novel approach to cancer treatment that leverages the versatility and specificity of DNA origami and nucleic acid-based therapeutic agents. The development of a DNA nanomachine, designed as a nano-barrel, showcases the potential for selective and effective tumor therapy through controlled release of therapeutic nucleic acid agents in response to cancer markers. This work offers a promising leap forward in the realm of targeted oncological therapies and the synergy of nanotechnology with molecular biology.

Хусейн З., Эльдиб А.А. (науч. рук. Колпащиков Д.М.) DESIGN AND DEVELOPMENT OF MARKER ACTIVATED NANOMACHINES USING DNA ORIGAMI FOR CANCER THERAPY // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2024]. URL: https://kmu.itmo.ru/digests/article/13588