Of all the actively developing areas of medicine, gene therapy is the most exciting. Anti-cancer gene therapeutics can help to overcome the existing problems of traditional cancer therapy, but they currently have low selectivity and efficacy. The current aim of our laboratory is to overcome these problems by creating a complex DNA nanorobot capable of recognising low concentrations of cancer-associated molecules (oncomarkers) and using logical calculations to perform therapeutic function by knocking down housekeeping genes. This study identified the most suitable cancer markers and developed a DNA machine capable of detecting their low concentrations. This development could form part of a future gene therapy agent with greater selectivity against cancer.

Куликова А.В., Патра Х.К., Асс В.Д. (науч. рук. Колпащиков Д.М.) Development of a dna-based nanoconstruction to detect low concentrations of cancer-associated molecules // Сборник тезисов докладов конгресса молодых ученых. Электронное издание. – СПб: Университет ИТМО, [2023]. URL: https://kmu.itmo.ru/digests/article/10991